The drama, which premiered on CBS in 2010, will draw to a close with a two-part 14th and final season, starting in February and finishing in autumn next year.
Tom, 78, stars as New York City Police Commissioner Frank Reagan in the hit series that follows members of his family, who all work in law enforcement, as they fight crime.
The Magnum PI actor began the role more than a decade after his first appearance as Monica Geller’s (Courteney Cox) boyfriend Dr Richard Burke in Friends.
In a statement, Tom said: ‘For the past 13 years it has been an honor and a privilege to work on a show that not only celebrates the men and women who protect and serve in New York City, but also displayed the importance of family.
‘Working alongside these incredible actors, writers, producers, directors and crew has been a dream come true and I’m grateful to have been a part of this extraordinary group for over 275 episodes.
‘Thank you to CBS Studios and CBS Network for their steadfast support and we offer heartfelt gratitude to the fans who gathered with us for dinner every Friday night.’
Blue Bloods cancellation was announced by the show’s official X, formerly known as Twitter, account in a tweet that read: ‘Join us for the final season of #BlueBloods Season 14, airing in TWO parts: February 2024 and Fall 2024 on @CBS and @paramountplus.’
Tom’s breakout role was playing private investigator Thomas Magnum in the television series Magnum, PI in the 80s.
Tom later appeared on Friends and is among the cast mourning Chandler Bing actor Matthew Perry’s death aged 54 last month after an apparent drowning in a hot tub at his LA home.
As well as the hit sitcom, Tom appeared in numerous other TV shows including Charlie’s Angels, Las Vegas and The Closer.
On the big screen, he is best known for playing bachelor architect Peter Mitchell in Three Men and a Baby and its sequel Three Men and a Little Lady.
His other film credits include Quigley Downunder, Mr Baseball and Lassiter.
Tom is currently readying for the May 2024 release of his memoir You Never Know, which will recall the actor’s ‘misfires and mistakes’ in his personal and professional life.
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